Chemoradiation Induces a Proangiogenic and Protumor Circulating Cytokine Profile

Circulating Proangiogenic Cells

Stem cell therapy could be a promising option for the treatment of vascular diseases. The finding of stem/progenitor cells in circulating blood and the vessel wall indicates that endogenous (adult) stem cells have the ability to repair endothelial cells, thereby restoring the integrity of the vessel and most importantly its function. However, embryonic stem cells, which are a population of undi...

A peripheral circulating TH1 cytokine profile is inversely associated with prostate cancer risk in CLUE II.

BACKGROUND TH1 cytokines, such as IFNγ and TNFα, and potentially innate cytokines, such as IL6, can potentiate the immune response to tumor. Cytokines, such as IL1β, IL8, and IL10, may suppress anticancer immunity. Thus, we prospectively evaluated the association between peripheral-cytokine concentrations and prostate cancer. METHODS We conducted an age-race matched case-control study (268 pa...

Circulating Cytokine/Inhibitor Profiles

Antimicrobial peptide Brevinin-2R induces the secretion of a pro-inflammatory cytokine in HepG2 cells

Introduction: Antimicrobial peptides as the body's defense strategy play an important role in resistance against infection of microorganism. These peptides are able to modulate the immune and inflammatory processes through the production of defensive molecules. Therefore, the modulatory effects of Brevinin-2R, an antimicrobial peptide extracted from the skin of the frog (Rana ridibunda), was ev...

Midkine acts as proangiogenic cytokine in hypoxia-induced angiogenesis.

The cytokine midkine (MK) promotes tumor growth mainly by inducing angiogenesis. Here, we identified the source of MK in the vascular system under hypoxic conditions and demonstrated the relevance of MK during ischemia of normal tissue. Hypoxia increased MK protein expression in human polymorphonuclear neutrophils (PMN), monocytes, and human umbilical vein endothelial cells (HUVEC) compared wit...